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Objective: Up to now, pediatric 18F-FDG dose and acquisition durations are generally based on coarse extrapolation from adult guidelines. This study sought to determine whether shorter acquisition durations or a lower 18F-FDG injected activity could be used during pediatric 18F-FDG PET/CT examinations while maintaining diagnostic utility. Methods: 36 whole-body 18F-FDG PET/CT examinations were performed on 36 patients (weight, 13-89 kg;46.51± 5.63 kg, age range, 3-14 y, 9.22± 3.16) with a weight-based injected activity (5.3 MBq/kg [0.144 mCi/kg]), fixed acquisition durations 180 S/FOV, Vip record acquisition mode using Discovery STE. For each examination, the Vip-mode data were truncated to form multiple datasets with shorter acquisition durations down to a minimum of 60 S/FOV (i.e., 60, 80,100,120,140,160 S/FOV data were formed from single 180 S/FOV acquisition). 168 image volumes were generated, randomized, and reviewed in a masked manner with corresponding CT image volumes by 6 radiologists. Overall, subjective adequacy and objective lesion detection accuracy by body region were evaluated. Results: All examinations with maximum acquisition duration were graded as adequate and were used as the reference standard for detection accuracy. For patients more than 30 kg,when acquisition duration was more than 120 S/FOV, all PET/CT examinations was graded as adequate for clinical tasks, whereas, acquisition duration was reduced less than 120 S/FOV, lesion detection became less accurate. For patients less than 30 kg,Lesion detection accuracy was perfect for acquisition times between 140 S/FOV and 180 S/FOV for all regions of the body. However, lesion detection became less accurate when imaging acquisition time was reduced less than 140 S/FOV. Conclusion: When GE Discovery STE PET/CT was applied during Pediatric PET/CT examination, Using decreased acquisition times as a surrogate for 18F-FDG dose, 18F-FDG dose can be reduced by approximately 33.33％, when patients lager than 30 kg were scanned for 180 S/FOV, for patients less than 30 kg, 18F-FDG dose can be reduced by approximately 22.22％ without a loss of diagnostic utility. Reduction of overall scan time potentially reduces motion artifacts, improves patient comfort, and decreases length of sedation.Altatively, decreased 18F-FDG dose minimizes radiation risk.