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心喘齐灵为我国合成的扩张冠状动脉、降压、抗心律失常、平喘新药。小鼠口服心喘齐灵急性中毒表现惊厥、死亡,LD_(50)为328.90±53.28mg/kg。Wistar 大鼠口服心喘齐灵53mg/kg/d,连续6个月引起 Hb 降低(p<0.05)、血 Na~+减少(p<0.05)和可逆性肝、肾轻度损害。26.8mg/kg/d 亦可引起Hb 降低(p<0.05)。但是,5.3mg/kg/d 无明显毒性,表明治疗量是安全的,这和临床报告一致。用豚鼠试验无速发型变态反应。
Xinchuan Qiling is a synthetic Chinese medicine that expands coronary arteries, blood pressure, antiarrhythmics, and asthma. The mice were orally consumed with acute asthmatic convulsion and convulsions and died. The LD_(50) was 328.90±53.28 mg/kg. Wistar rats were treated with oral asthma Chuanling 53mg/kg/d for 6 consecutive months, causing Hb reduction (p<0.05), blood Na~+ reduction (p<0.05), and reversible mild liver and kidney damage. 26.8mg/kg/d also caused a decrease in Hb (p<0.05). However, no significant toxicity was observed at 5.3 mg/kg/d, indicating that the therapeutic dose was safe, which is consistent with the clinical report. No anaphylactic allergy was tested in guinea pigs.