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目的:探讨液基薄层细胞学(TCT)配合阴道镜诊断及组织活检对宫颈病变的诊断价值。方法:在TCT检查的4189例女性中,对TCT报告ASCUS以上、阴道镜诊断RCI评分>2分以上的458例进行组织活检联合诊断,并统计其符合率。结果:458例TCT与组织活检的符合率为77.9%,阴道镜诊断与组织活检符合率为82.3%;单纯TCT、阴道镜诊断与组织活检对照结果符合率差异有统计学意义(P<0.01);但对TCT细胞学HSIL以上及阴道镜诊断RCI综合评分CINⅠ三级以上同时阳性的123例,与组织活检对照符合率为96.7%,差异无统计学意义(P>0.01)。结论:TCT筛查配合阴道镜诊断能显著提高宫颈病变的检出率,尤其是对早期诊断宫颈癌和癌前病变具有一定的价值,适合临床广泛应用。
Objective: To investigate the diagnostic value of liquid-based thin-layer cytology (TCT) combined with colposcopy and biopsy on the diagnosis of cervical lesions. Methods: Of the 4189 women examined by TCT, 458 cases with ASCT diagnosed by TCT and more than 2 points by colposcopy were diagnosed by biopsy and the coincidence rates were calculated. Results: The coincidence rate of TCT and tissue biopsy was 77.9% in 458 cases and 82.3% in colposcopy diagnosis and biopsy. The coincidence rate of TCT, colposcopy and biopsy was statistically significant (P <0.01) However, 123 cases with positive third grade and above grade CINI in TCT cytology HSIL and colposcopy were 96.7%, which showed no significant difference (P> 0.01). Conclusion: TCT screening combined with colposcopy can significantly improve the detection rate of cervical lesions, especially for early diagnosis of cervical cancer and precancerous lesions of a certain value, suitable for clinical application.