选择性环氧合酶 2 (COX 2 )抑制剂已成为寻找副作用小的、非甾体类抗炎药的研究方向。美洛昔康与氯诺昔康是两种结构不同的昔康类非甾体抗炎药 ,所具有的消炎镇痛作用及良好的胃肠道耐受性与它们对COX 2的选择性抑制作用有关。本文报道了美洛昔康和氯诺昔康对COX 2的选择性抑制作用及相应的药效学和药动学性质。 Selective cyclooxygenase 2 (COX 2) inhibitors have been the search for less-toxic, non-steroidal anti-inflammatory drugs. Meloxicam and lornoxicam are two different kinds of oxcarbazone non-steroidal anti-inflammatory drugs with anti-inflammatory and analgesic effects and good gastrointestinal tolerance and their selective inhibition of COX 2 Relevant role. This article reports the selective inhibition of meloxicam and lornoxicam on COX 2 and its pharmacodynamic and pharmacokinetic properties.