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肾上腺分泌多种激素,可直接影响胃肠道的功能。其中主要是糖皮质激素,其次是醛固酮、肾上腺素及去甲基肾上腺素。一、肾上腺激素与胃肠道功能(一)糖皮质激素:生理情况下,糖皮质激素对维持胃肠道的运动功能、分泌功能和小肠的吸收功能都有重要作用。过量的糖皮质激素可使胃粘膜壁细胞增多,增加胃酸分泌;胃蛋白酶原分泌增多;胃粘液分泌减少,伴胃粘膜分泌粘液组成的改变,使胃粘膜的保护作用削弱;粘膜细胞内DNA合成不足,胃粘膜细胞的更新减少;对组织胺和迷走神经兴奋的分泌性反应增强。长期服用皮质激素后,血中胃泌素含量升高,后者
Adrenal secretion of a variety of hormones, gastrointestinal function can be directly affected. Mainly glucocorticoid, followed by aldosterone, epinephrine and norepinephrine. First, the adrenal hormones and gastrointestinal function (A) glucocorticoid: Physiological circumstances, glucocorticoids maintain gastrointestinal motility, secretion and intestinal absorption have an important role. Excessive glucocorticoid can increase the number of gastric mucosa parietal cells, increase gastric acid secretion; increased secretion of pepsinogen; gastric mucus secretion decreased with mucosal mucosal secretions change the composition of the mucosal protective effect of the weakened; mucosal intracellular DNA synthesis Inadequate, gastric mucosal cell renewal decreased; on the histamine and vagus nerve stimulated secretion response increased. Long-term use of corticosteroids, blood gastrin levels, the latter