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目的：探讨高原肺原性心脏病（肺心病）夜间减氧饱和（ＮＯＤ）与生存的关系。方法：对４６例日间动脉血氧分压（ＰａＯ２）＞６．６６ｋＰａ高原肺心病缓解期患者作日间动脉血气分析、肺功能和夜间血氧饱和度（ＳａＯ２）连续监测。结果：①与非ＮＯＤ组比较，ＮＯＤ组日间ＰａＯ２明显低于非ＮＯＤ组；ＰａＣＯ２明显高于非ＮＯＤ组；１秒钟用力呼气容积（ＦＥＶ１．０）／身高（Ｈｔ）、ＦＥＶ１．０／ＦＶＣ（用力肺活量）、Ｖ５０／Ｈｔ、Ｖ２５／Ｈｔ也明显低于非ＮＯＤ组；ＮＯＤ组睡眠平均ＳａＯ２和最低ＳａＯ２明显低于非ＮＯＤ组；平均生存时间和５年生存率ＮＯＤ组明显低于非ＮＯＤ组。②ＦＥＶ１．０／Ｈｔ、ＦＥＶ１．０／ＦＶＣ、Ｖ５０／Ｈｔ与生存时间也有相关性。③结论：高原肺心病ＮＯＤ与其预后有明显关系，ＦＥＶ１．０／Ｈｔ、ＦＥＶ１．０／ＦＶＣ、Ｖ５０／Ｈｔ对判断预后也有价值，建议此类患者应监测夜间ＳａＯ２及进行长期氧疗。
Objective: To investigate the relationship between nocturnal hypoxia saturation (NOD) and survival in patients with high altitude pulmonary heart disease (pulmonary heart disease). Methods: Forty-six patients with remission of pulmonary heart disease during the period of PaO2> 6.66 kPa were monitored continuously for pulmonary arterial blood gas analysis, pulmonary function and night oxygen saturation (SaO2). Results: Compared with non-NOD group, PaO2 in NOD group was significantly lower than that in non-NOD group; PaCO2 was significantly higher than non-NOD group; FEV1.0 / Ht, FEV1.0 / FVC (forced vital capacity), V50 / Ht, V25 / Ht also significantly lower than non-NOD group; NOD group sleep average SaO2 and lowest SaO2 was significantly lower than non-NOD group; mean survival time and 5-year survival rate was significantly lower in NOD group Non-NOD group. ② FEV1.0 / Ht, FEV1.0 / FVC, V50 / Ht and survival time are also related. ③ Conclusion: There is a clear relationship between NOD and prognosis of plateau pulmonary heart disease. FEV1.0 / Ht, FEV1.0 / FVC and V50 / Ht are also valuable in predicting prognosis. It is suggested that such patients should monitor nighttime oxygenation of SaO2 and long-term oxygenation.