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目的:观察雷贝拉唑联合枳术宽中胶囊治疗反流性食管炎的疗效。方法:选择反流性食管炎60例,随机分为雷贝拉唑组(A组)、枳术宽中胶囊组(B组)及雷贝拉唑联合枳术宽中胶囊组(C组)各20例,疗程均为8周,观察比较3组治疗前后临床症状改善情况、症状积分和胃镜下疗效。结果:治疗后3组临床症状均有显著改善,症状积分较治疗前显著下降,胃镜下食管炎显著改善(P<0.01),但C组症状积分下降和总有效率均显著高于A、B组(P<0.05)。结论:雷贝拉唑联合枳术宽中胶囊治疗反流性食管炎疗效优于单用雷贝拉唑或枳术宽中胶囊。
Objective: To observe the efficacy of rabeprazole combined with Zhizhu Kuanzhong Capsule in the treatment of reflux esophagitis. Methods: 60 cases of reflux esophagitis were randomly divided into rabeprazole group (A group), Zhizhu Kuanzhong Capsule group (B group) and rabeprazole combined Zhizhu Kuanzhong Capsule group (C group) Each of 20 cases was treated for 8 weeks. The clinical symptoms, symptom scores and endoscopic effects before and after treatment were observed and compared between the three groups. Results: After treatment, the clinical symptoms were significantly improved in all three groups. Symptom scores decreased significantly compared with before treatment, and endoscopic esophagitis was significantly improved (P <0.01). However, the symptom scores and total effective rate in group C were significantly higher than those in group A and B Group (P <0.05). Conclusion: Rabeprazole combined with Zhizhu Kuanzhong Capsule is superior to rabeprazole or Zhizhu Kuanzhong capsule in the treatment of reflux esophagitis.