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在各种致癌因子中对砷的意见分歧最大了。反对和怀疑砷致癌的意见直到不久以前还有相当影响。这种观点容易使人们忽略砷这种广泛存在的致癌因子,从而放松对它的警惕。因此回顾砷癌的历史,弄清争议的焦点,对正确认识和估计砷癌的危害有现实意义。砷致癌说本始于Paris(1820),他认为英国冶炼厂工人患阴囊癌,是由该厂烟尘中的砷所致。自Hutchinson(1887)提出“砷→掌蹠皮肤角化→皮肤癌的公式”后,砷致癌说才取得重大进展。他报告6例病人,服用含砷药物
The disagreement on arsenic among various carcinogenic factors is the greatest. Opposition to and suspicion of arsenic-caused opinion has had considerable influence until recently. This view makes it easy for people to ignore the widespread presence of arsenic, a carcinogen, and thus relax its vigilance. Therefore, it is of practical significance to review the history of arsenic cancer and clarify the focus of the controversy in order to correctly understand and estimate the risk of arsenic cancer. The arsenic carcinogens started in Paris (1820). He believes that British smelter workers suffer from scrotal cancer due to arsenic in the smoke from the plant. Since Hutchinson (1887) put forward the “arsenic → palmoplantar skin keratinization → skin cancer formula”, arsenic carcinogenicity has made significant progress. He reported 6 patients taking arsenic-containing drugs