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女性宫颈阴道部与阴道穹窿部的上皮细胞称作人外宫颈-阴道部上皮细胞(human ectocer-vical-vaginal epithelial cell,hECE)。人外宫颈-阴道部上皮细胞(hECE)在维持阴道内液体微环境上起重要作用。女性下生殖道中,分泌上皮主要的运输通道是细胞旁通道,此通道的电阻由紧密连接电阻(RTJ)和外侧细胞间隙电阻(RLIS)组成。最近在hECE研究中发现了新的调节细胞旁电阻(RPCR)的机制,雌激素通过调节RTJ和RLIS,能够影响hECE的渗透性,这些作用机制能够提供临床绝经期出现的水和电解质失调以及相关疾病的理论依据,并对进一步提出解决方案有指导意义。
Epithelial cells of the female cervicovaginal and vaginal vault are called human ectocervical-vaginal epithelial cells (hECE). Human external cervical-vaginal epithelial cells (hECE) play an important role in maintaining intravaginal fluid microenvironment. In the female lower genital tract, the major transport channel for the secretory epithelium is the paracellular passageway whose resistance consists of tight junction resistance (RTJ) and lateral interstitial resistance (RLIS). Recently a new mechanism for regulating cell paracellular resistance (RPCR) was discovered in the hECE study. Estrogen can affect the permeability of hECE by modulating RTJ and RLIS, and these mechanisms of action can provide water and electrolyte imbalances associated with clinical menopause The theoretical basis of the disease, and guidance for further proposed solutions.