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目的分析药物不良反应(ADR)发生的情况、特点及相关因素,为临床合理用药提供参考。方法收集医院2015年7月-2016年6月通过网上电子系统上报的有效ADR共178例,采用回顾性方法对患者基本情况、怀疑药品、给药途径、合并用药、ADR累及器官或系统、临床表现、转归等进行评价分析。结果 178例ADR中女性高于男性,抗感染药和中药制剂的ADR最高,分别为29.78%和23.60%;静脉滴注占117例;皮肤及其附件损害为最常见。结论抗感染药和中药制剂是ADR监测的重点药物,静脉给药是ADR监测的重点途径,用药过程中应注意皮肤及其附件的损害信号。
Objective To analyze the situation, characteristics and related factors of adverse drug reaction (ADR) and provide reference for clinical rational drug use. Methods A total of 178 valid ADRs reported by online electronic system from July 2015 to June 2016 were collected retrospectively. The data of patients’ basic conditions, suspected drugs, route of administration, combination therapy, ADR involved organ or system, clinical Performance, outcome and other evaluation analysis. Results The ADR of 178 women was higher than that of men. The highest ADR were anti-infective medicine and traditional Chinese medicine, accounting for 29.78% and 23.60% respectively; intravenous drip (117 cases); skin and its accessory lesions were the most common. Conclusion Anti-infectives and traditional Chinese medicine preparations are the key drugs for ADR monitoring. Intravenous administration is the key way of ADR monitoring. During the course of medication, the damage signals of the skin and its appendages should be noticed.