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目的考察诱发妊娠期糖尿病孕妇合并子痫前期的相关风险因素及其对妊娠结局的影响。方法选取2015年1-12月在该院就诊的无合并子痫前期的妊娠期糖尿病孕妇90例为对照组,合并子痫前期的妊娠期糖尿病孕妇70例为观察组。分别采集两组患者空腹血糖(FBG)、糖化血红蛋白(HbALc)、血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDLc)、肌氨酸酐(Creatinine)及体重指数(BMI),分析对比两组患者各生化指标含量及BMI的差异。观察记录两组早产、胎儿窘迫、宫内感染、巨大儿、新生儿窒息、胎儿宫内生长受限和胎膜早破等不良妊娠结局的发生率。结果观察组患者FBG、TC、TG、LDLc、Creatinine及BMI均显著高于对照组,差异有统计学意义(P<0.05)。观察组患者胎儿窘迫、新生儿窒息、胎儿宫内生长受限等不良结局发生率显著高于对照组,差异有统计学意义(P<0.05)。结论妊娠期糖尿病孕妇FBG、TC、TG、LDLc、Creatinine及BMI含量是诱导发生妊娠期糖尿病合并子痫前期的相关危险因素,妊娠期糖尿病合并子痫前期孕妇的不良妊娠结局发生率较高。
Objective To investigate the risk factors associated with preeclampsia in pregnant women with gestational diabetes mellitus and their effects on pregnancy outcomes. Methods Ninety pregnant women with gestational diabetes without preeclampsia treated in this hospital from January to December in 2015 were selected as the control group. 70 pregnant women with gestational diabetes mellitus with preeclampsia were selected as the observation group. The levels of fasting blood glucose (FBG), HbAlc, TC, TG, LDLc, Creatinine and body mass index BMI), analysis and comparison of two groups of patients with biochemical parameters and BMI differences. The incidence of adverse pregnancy outcomes such as preterm birth, fetal distress, intrauterine infection, macrosomia, neonatal asphyxia, fetal growth restriction and premature rupture of membranes were observed and recorded. Results The FBG, TC, TG, LDLc, Creatinine and BMI in the observation group were significantly higher than those in the control group (P <0.05). The incidence of adverse outcomes such as fetal distress, neonatal asphyxia and limited intrauterine growth in the observation group were significantly higher than those in the control group (P <0.05). Conclusion The levels of FBG, TC, TG, LDLc, Creatinine and BMI in pregnant women with gestational diabetes mellitus are the risk factors for inducing gestational diabetes mellitus with preeclampsia. The prevalence of adverse pregnancy outcomes in gestational diabetes mellitus with preeclampsia is high.