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目的评价咖啡因清除试验作为定量肝功能试验的临床应用价值。方法口服２５０ｍｇ咖啡因后测定二次受试者血药浓度，计算咖啡因清除率。共检测２３例对照组及６０例各种肝病患者。结果对照组咖啡因清除率（ＣＬ）为１．６０±０．４ｍｌ／ｋｇ·ｍｉｎ－１，慢性肝炎、酒精性肝病患者的ＣＬ轻度降低，肝硬化组严重降低。肝硬化患者的ＣＬ与Ｃｈｉｌｄ评分呈明显负相关；ＣＬ极度降低者生存期短。以对照组ＣＬ的－１ｓ为临界值，则本试验对肝功能异常的敏感度为８８．３３％，特异度为８６．９６％，准确度为９１．２５％。结论咖啡因清除试验是一个方便、可靠的肝脏贮备功能指标。
Objective To evaluate the clinical value of caffeine clearance test as a quantitative liver function test. Methods After oral administration of 250 mg of caffeine, the plasma concentration of secondary subjects was measured to calculate the caffeine clearance rate. A total of 23 cases of control group and 60 cases of liver disease were detected. Results The caffeine clearance (CL) of the control group was 1.60 ± 0.4ml / kg · min-1. The levels of CL in patients with chronic hepatitis and alcoholic liver disease were significantly lower than those in patients with cirrhosis. There was a significant negative correlation between CL and Child score in patients with cirrhosis; short-term CL was extremely low. To the control group CL -1s as the critical value, the test of liver function abnormalities was 88.33% sensitivity, specificity of 86.96%, accuracy of 91.25%. Conclusion Caffeine clearance test is a convenient and reliable indicator of liver reserve function.