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目的探讨沙利度胺口服联合醋酸曲安奈德局部注射治疗口腔扁平苔藓(OLP)临床效果。方法对2009年7月—2011年7月郑州市口腔医院牙周黏膜科64例口腔扁平苔藓患者随机分为观察组和对照组,观察组予以沙利度胺片剂口服和醋酸曲安奈德注射液和2%利多卡因局部黏膜下注射,对照组采用醋酸曲安奈德注射液及2%利多卡因局部黏膜下注射,通过临床症状判定疗效。结果观察组的总有效率为96.8%,高于对照组90.6%,观察组满意率96.8%,高于对照组87.5%。结论采用口服用药和局部注射相结合的方法对于治疗OLP有更好的临床疗效。
Objective To investigate the clinical effect of oral administration of thalidomide combined with triamcinolone acetonide for the treatment of oral lichen planus (OLP). Methods From July 2009 to July 2011, 64 patients with oral lichen planus in periodontal mucosa of Zhengzhou Stomatological Hospital were randomly divided into observation group and control group. The observation group was treated with thalidomide tablets orally and triamcinolone acetonide injection Liquid and 2% lidocaine local submucosal injection, the control group with triamcinolone acetonide injection and 2% lidocaine local submucosal injection, to determine the efficacy of clinical symptoms. Results The total effective rate of the observation group was 96.8%, higher than that of the control group 90.6%. The satisfaction rate of the observation group was 96.8%, which was 87.5% higher than that of the control group. Conclusion The combination of oral drug administration and local injection has better clinical efficacy for the treatment of OLP.