论文部分内容阅读
目的检测刺五加注射液在临床上对肢体缺血再灌注损伤是否有保护作用。方法将48例择期下肢手术的患者,随机分成对照组和用药组,用药组在上止血带前30min静滴生理盐水加刺五加注射液,对照组在上止血带前30min静滴同量的生理盐水,均于20min内滴完,在止血带充气前(T0),止血带放气后0~1min(T1)、30min(T2)于患肢各抽取静脉血,检测血清肌酸激酶(CK)和丙二醛(MDA)变化。结果刺五加注射液能使止血带引起的肢体缺血再灌注后的血清CK、MDA值较对照组明显降低。结论刺五加注射液对止血带引起的肢体缺血再灌注损伤具有保护作用。
Objective To investigate whether acanthopanax senticosus injection has a protective effect on limb ischemia-reperfusion injury in clinic. Methods Forty-eight patients undergoing lower extremity surgery were randomly divided into control group and medication group. The rats in the medication group were given normal saline and Acanthopanax senticosus injection 30 minutes before the tourniquet, while the control group received the same amount of intravenous infusion 30 minutes before the tourniquet, (10 min before the tourniquet was inflated), venous blood was collected from the affected limbs at 0 ~ 1 min (T1) and 30 min (T2) after the tourniquet was deflated, and serum creatine kinase (CK ) And malondialdehyde (MDA) changes. Results Acanthopanax senticosus injection can make tourniquet-induced limb ischemia-reperfusion serum CK, MDA values were significantly lower than the control group. Conclusion Acanthopanax senticosus injection has a protective effect on tourniquet-induced limb ischemia-reperfusion injury.