报告1例皮肤转移性印戒细胞癌。患者,女,56岁。躯干四肢多发疣状斑块1年半,左侧头面部疼痛5个月。右下眼睑肥厚性丘疹。组织病理检查示真皮散在或成片异型细胞浸润,核深染偏一侧,胞浆丰富,部分细胞呈印戒样。免疫组化示CK(+),AB/PAS(+)。诊断为皮肤转移性印戒细胞癌。骨髓活检组织病理示骨髓转移性印戒细胞癌。全身骨ECT示肿瘤全身骨转移。妇科B超示右侧附件区实质性包块为右卵巢转移可能。未能发现原发肿瘤。 One case of skin metastatic signet ring cell carcinoma was reported. Patient, female, 56 years old. Trunk multiple verrucous plaque 1.5 years, left head and face pain for 5 months. Lower right eyelid hypertrophic papules. Histopathological examination showed that the dermis scattered or into pieces of abnormal cell infiltration, nuclear deep stained side, rich in cytoplasm, some cells were signet-ring-like. Immunohistochemistry showed CK (+), AB / PAS (+). Diagnosis of skin metastatic signet ring cell carcinoma. Bone marrow biopsy showed bone marrow metastatic signet ring cell carcinoma. Whole body bone ECT showed tumor bone metastasis. Gynecological B-ultrasound showed the right mass attachment block right ovarian metastasis may be. Failed to find the primary tumor.