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一氧化氯(NO)是一种内源性血管舒张剂、炎症介质、血小扳聚集抵制因子和神经递质,它在肝硬化门脉高压症中起了重要作用。NO产生受血浆内毒素水平的影响。内毒素通过诱导肝细胞释放NO。本实验采用抑制肠源性内毒素血症的药物丽珠肠乐口服,结果表明:服用丽珠肠乐一个疗程后,血浆NO水平显著下降(P<0.01),白蛋白合成增多,门脉压力下降,肝功能显著改善,有利于腹水消退,减少并发症的产生。
Nitric oxide (NO) is an endogenous vasodilator, inflammatory mediators, aggregation factors and neurotransmitters that play an important role in cirrhosis and portal hypertension. The production of NO is affected by plasma endotoxin levels. Endotoxins release NO by inducing hepatocytes. In our study, we took oral administration of Lizhu Gutta for oral endotoxemia, and the results showed that after a course of treatment with Ligustrum enteral, plasma NO levels decreased significantly (P <0.01), albumin synthesis increased, and portal pressure Decline, significant improvement of liver function, is conducive to ascites subsided, reducing the incidence of complications.