当单一药物治疗无效时,常联合应用抗心律失常药物。临床研究证实联合用药增加疗效,根据心律失常的机理而采用的联合治疗更易于成功。联合用药可减少药物的有效剂量,与剂量有关的副作用较少。本文综述最常用的抗心律失常药物的联合应用,并讨论其优点和可能的缺点。第Ⅰ类抗心律失常药物的联合应用第Ⅰ类抗心律失常药物干扰细胞膜除极。本类药物根据其对复极的影响分为三组。该类药物抑制受损心肌细胞的传导性并抑制其异常自律性,其主要电生理作用是降低最大除极速率而不影响静息膜电位。该作用是 When a single drug is ineffective, antiarrhythmic drugs are often given in combination. Clinical studies confirm that combination therapy increases efficacy and that combination therapy based on the mechanism of arrhythmia is more likely to succeed. Combination therapy can reduce the effective dose of the drug dose-related side effects less. This article reviews the most commonly used combination of antiarrhythmic drugs and discusses its advantages and possible disadvantages. Class Ⅰ Antiarrhythmic Drug Combination Class I antiarrhythmic drugs interfere with cell membrane depolarization. The drugs are divided into three groups based on their impact on repolarization. These drugs inhibit the conduction of damaged cardiomyocytes and inhibit their abnormal self-regulation, the main electrophysiological effect is to reduce the maximum rate of depolarization without affecting the resting membrane potential. This effect is