血清CXCL12、CCL2、RANTES和孕酮在胚胎发育不良早期诊断中的作用

来源 :中国妇幼保健 | 被引量 : 0次 | 上传用户:kkk00011123
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
目的:探讨血清基质细胞衍生因子(CXCL12)、单核细胞趋化蛋白-1(CCL2)、调节活化正常T细胞表达和分泌因子(RANTES)和孕酮在胚胎停育早期诊断中的作用。方法:选择2008年6月~2009年6月在天津医科大学第二医院计划生育科因胚胎停育就诊的患者26例(胚胎停育组)以及同孕龄正常早孕妇女30例(对照组),采用酶联免疫技术检测血清CXCL12、CCL2和RANTES的蛋白含量,采用化学发光免疫分析技术检测血清孕酮的水平。结果:胚胎停育组血清CXCL12的蛋白含量为(194.52±29.23)pg/ml,低于对照组[(268.13±26.36)pg/ml],差异有统计学意义(P<0.05);CCL2和RANTES的蛋白含量分别为(83.34±10.6l)pg/ml和(117.29±18.67)pg/ml,高于对照组[(59.41±9.70)pg/ml和(79.88±12.54)pg/ml],差异均有统计学意义(P<0.05)。血清孕酮水平为(29.66±6.41)ng/ml,低于对照组[(10.06±2.86)ng/ml],差异有统计学意义(P<0.05)。两组血清CXCL12值与孕酮值呈正相关关系(γ=0.765,P<0.05);血清CCL2、RANTES值与孕酮值呈负相关关系(γ=-0.703,P<0.05;γ=-0.692,P<0.05)。结论:联合单次检测血清CXCL12、CCL2、RANTES和孕酮在胚胎停育的早期诊断中具有重要的临床意义,孕激素可能对早孕母胎界面趋化因子CXCL12、CCL2、RANTES有免疫调节作用。 Objective: To explore the role of serum CXCL12, CCL2, RANTES and progesterone in the early diagnosis of embryo shutdown. Methods: Twenty-six patients (embryo stop group) and 30 normal pregnant women (control group) who were treated by the family planning family planning department of the Second Hospital of Tianjin Medical University from June 2008 to June 2009 were enrolled in this study. The protein levels of serum CXCL12, CCL2 and RANTES were detected by enzyme linked immunosorbent assay (ELISA), and the level of serum progesterone was detected by chemiluminescence immunoassay. Results: The protein level of serum CXCL12 in embryo stop group was (194.52 ± 29.23) pg / ml, which was lower than that in control group [(268.13 ± 26.36) pg / ml] (83.34 ± 10.61) pg / ml and (117.29 ± 18.67) pg / ml, respectively, which were higher than that of the control group [(59.41 ± 9.70) pg / ml and (79.88 ± 12.54) pg / ml] There was statistical significance (P <0.05). The level of serum progesterone was (29.66 ± 6.41) ng / ml, which was lower than that of the control group [(10.06 ± 2.86) ng / ml], the difference was statistically significant (P <0.05). There was a positive correlation between serum CXCL12 and progesterone (γ = 0.765, P <0.05). There was a negative correlation between serum CCL2 and RANTES and progesterone (γ = -0.703, P <0.05; P <0.05). CONCLUSION: The combination of single serum CXCL12, CCL2, RANTES and progesterone has important clinical significance in the early diagnosis of embryo shutdown. Progesterone may have immunomodulatory effects on the expression of CXCL12, CCL2 and RANTES.
其他文献
为使接送手术病人过程中所有人员的责任分工明确,各司其职,以提高护理质量,确保病人安全,我们于2003年10月份自行设计了“手术病人接送交接单”,经过3年,接送26 000多例手术
产后出血是产科常见并发症,产后出血的发生率为2%~11%.据流行病学调查,产后出血仍为产妇死亡的首要原因[1].
期刊
抑郁症是以情绪低落,持续性疲乏,动力缺乏等为核心症状群的一种精神障碍性疾病.抑郁症又分为原发性抑郁和继发性抑郁两大类,综合性医院住院病人以继发性抑郁多见,常继发于脑
目的:了解待产孕妇血清中两种邻苯二甲酸酯(PAEs)水平,探讨血清PAEs水平与胎儿生长发育的关系.方法:收集150例武汉市某三级医院待产孕妇血清,采用反相高效液相色谱分析法(HPL
随着生命科学的发展,护理范畴和内涵逐步扩大,护理新技术、新业务越来越多地被临床应用,在护理实践中不断寻求更简便、更省力的护理方法,对护理工作流程、护理操作程序进行创
自尊是自我概念的一种评价和体验,并且与心理健康息息相关.在临床中自我概念紊乱是公认的护理诊断,为此,在临床或社区中护士应准确识别患者的自尊水平,维护患者自尊,从而提高