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目的：探讨高压氧（ＨＢＯ）对新生大鼠缺氧缺血性脑病（ＨＩＥ）的影响。方法：将７日龄ＳＤ新生大鼠随机分为对照组、ＨＩＥ组和ＨＢＯ治疗组。在实验第７天后处死动物。测定病侧脑组织匀浆超氧化物歧化酶（ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨ－ＰＸ）和丙二醛（ＭＤＡ）含量。结果：（１）ＨＩＥ模型组ＳＯＤ、ＧＳＨ－ＰＸ活力明显低于对照组（Ｐ＜０．０００３，Ｐ＜０．００６），而ＭＤＡ含量显著高于对照组（Ｐ＜０．００３）；（２）ＨＩＥ组ＨＢＯ治疗１周后，脑组织中ＳＯＤ、ＧＳＨ－ＰＸ活力明显高于未治疗ＨＩＥ组（Ｐ＜０．０００３，Ｐ＜０．００６），而ＭＤＡ含量低于未治疗ＨＩＥ组（Ｐ＜０．００３）。结论：ＨＢＯ能增加ＨＩＥ脑组织内自由基清除酶类的活力，降低局部脂质过氧化物的含量
Objective: To investigate the effect of hyperbaric oxygen (HBO) on neonatal hypoxic-ischemic encephalopathy (HIE). Methods: 7-day-old SD neonatal rats were randomly divided into control group, HIE group and HBO treatment group. Animals were sacrificed on day 7 of the experiment. The contents of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) and malondialdehyde (MDA) in the diseased brain tissue were measured. Results: (1) The activities of SOD and GSH-PX in HIE model group were significantly lower than those in control group (P <0.0003, P <0.006), while the content of MDA in HIE model group was significantly higher than that in control group (P <0.003) 2) After 1 week HBO treatment in HIE group, the activity of SOD and GSH-PX in brain tissue was significantly higher than that of untreated HIE group (P <0.0003, P <0.006), while the MDA content was lower in untreated HIE group P <0.003). Conclusion: HBO can increase the activity of free radical scavenging enzymes in HIE brain tissue and decrease the content of local lipid peroxides