树突状细胞(DC)是专职抗原提呈细胞,具有启动免疫应答,调节T细胞反应的功能。在多发性硬化免疫病理反应过程中,脑脊液内DC具有摄取髓鞘抗原迁移至外周,激活外周初始型T细胞作用;而脑实质内DC可激活T细胞产生持续性损伤。同时,不成熟DC、某些亚型DC和经不同处理DC参与诱导多发性硬化的免疫耐受。因此,DC在多发性硬化发病中发挥重要作用。 Dendritic cells (DCs) are specialized antigen-presenting cells that have the function of initiating an immune response and regulating T cell responses. In the process of multiple sclerosis immunopathology, DC in cerebrospinal fluid has the function of uptake of myelin antigens to the periphery and activation of peripheral naive T cells; DCs in brain parenchyma activate persistent T cells. Meanwhile, immature DCs, some subtypes of DCs, and DCs that are differently treated are involved in the induction of immune tolerance to multiple sclerosis. Therefore, DC plays an important role in the pathogenesis of multiple sclerosis.