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目的 :比较个体化给药和传统给药方式对升压药疗效的影响。方法 :实验性出血性休克家兔 ,一组 (CAIMA组 )用电脑实时监测血压 ,并由电脑自动控制间羟胺的给药速率 ,使血压维持在预置水平 ;另一组 (非CAIMA组 )用等量间羟胺匀速滴入 ;两组均联合应用山莨菪碱。结果 :CAIMA组血压稳定地维持在预置水平 ,血乳酸和肌酐值渐降 ;非CAIMA组血压有下降趋势 ,血乳酸和肌酐值有上升趋势。结论 :CAIMA组疗效优于非CAIMA组 ,因为CAIMA是按个体需求形成间歇性不规则给药方式 ,起到了智能泵的作用 ,真正体现了个体化给药的优点。
Objective: To compare the effects of individualized administration and traditional administration on the efficacy of antihypertensive drugs. Methods: In experimental hemorrhagic shock rabbits, one group (CAIMA group) used computer to monitor the blood pressure in real time and the computer controlled the delivery rate of hydroxylamine among the rabbits. The blood pressure was maintained at the preset level. In the other group (non-CAIMA group) With the same amount of hydroxylamine uniform drip; two groups were combined application of anisodamine. Results: The blood pressure in CAIMA group was maintained at a preset level with the blood lactate and creatinine values gradually decreasing. The blood pressure in non-CAIMA group showed a decreasing trend while the blood lactate and creatinine level increased. Conclusion: The CAIMA group is superior to the non-CAIMA group because the CAIMA is an intermittent irregular drug delivery method based on individual needs. It plays a role of an intelligent pump and truly demonstrates the advantages of individualized administration.