The article introduces the unique characteristics of CNC machining center cutter compared to traditional cutters,analyzes the choice of CNC machining cutter and factors of choice.Meanwhile,proved by the examples with manufacture software CAXA2004,the correct choice of CNC machining center cutter can give full play to the advantages of CNC machining and improve the economic efficiency and production levels of enterprises. The article introduces the unique characteristics of CNC machining center cutter compared to traditional cutters, analyzes the choice of CNC machining cutter and factors of choice .Meanwhile, proved by the examples with manufacture software CAXA2004, the correct choice of CNC machining center cutter can give full play to the advantages of CNC machining and improve the economic efficiency and production levels of enterprises.