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1971年Lucas等〔1〕首次报道了应激性溃疡,危重症患者存在多种发生应激性溃疡的危险因素。据报道,多器官功能障碍综合征(multiple organ dysfunction syndrome,MODS)等危重症患者的应激性胃黏膜损伤的发生率为75%~100%。应激性溃疡将增加MODS患者的病死率和ICU住院时间,因此MODS患者应激性溃疡的预防和治疗显得尤为重要。
1971 Lucas et al 〔1〕 for the first time reported stress ulcer, critically ill patients there are a variety of stress ulcer risk factors. It has been reported that the incidence of stressful gastric mucosal injury in critically ill patients with multiple organ dysfunction syndrome (MODS) ranges from 75% to 100%. Stress ulcer will increase mortality and ICU hospital stay in patients with MODS, so the prevention and treatment of stress ulcer in MODS patients is particularly important.