Seperated heat pipe systems are widely used in the fields of waste heat recovery and air conditioning due to their high heat transfer capability,and optimization of heat transfer process plays an important role in high-efficiency energy utilization and energy conservation.In this paper,the entransy dissipation analysis is conducted for the separated heat pipe system,and the result indicates that minimum thermal resistance principle is applicable to the optimization of the separated heat pipe system.Whether in the applications of waste heat recovery or air conditioning,the smaller the entransy-dissipation-based thermal re-sistance of the separated heat pipe system is,the better the heat transfer performance will be.Based on the minimum thermal resistance principle,the optimal area allocation relationship between evaporator and condenser is deduced,which is numeri-cally verified in the optimation design of separated heat pipe system. Seperated heat pipe systems are widely used in the fields of waste heat recovery and air conditioning due to their high heat transfer capability, and optimization of heat transfer process plays an important role in high-efficiency energy utilization and energy conservation. In this paper, the entransy dissipation analysis is conducted for the separated heat pipe system, and the result indicates that minimum thermal resistance principle is applicable to the optimization of the separated heat pipe system. WHether in the applications of waste heat recovery or air conditioning, the smaller the entransy- dissipation-based thermal re-sistance of the separated heat pipe system is, the better the heat transfer performance will be based on the minimum thermal resistance principle, the optimal area allocation relationship between evaporator and condenser is deduced, which is numeri-cally verified in the optimation design of separated heat pipe system.