脂质体及其它微粒药物载体应用的主要局限性,是易被网状内皮系统的细胞、特别是肝和脾的单核吞噬细胞迅速从血液清除。尽管脂质体的组织分布可因粒径、组分(电荷)、给药途径及掺入抗体或靶细胞受体的配体而稍有改变,但吞噬细胞仍是主要的靶细胞。由于肝吞噬细胞清除血内异物的功能以及肝细胞与血液的密切关系,使肝脏成为脂质体的重要靶器官;而肝脏丰富的营养环境又为许多寄生虫提供繁殖场所。因而,尝试 The main limitation of the use of liposomes and other particulate drug carriers is that they are readily cleared from the blood by mononuclear phagocytes of the reticuloendothelial system, especially the liver and spleen. Although the tissue distribution of liposomes may vary slightly depending on particle size, composition (charge), route of administration, and ligand incorporated into the antibody or target cell receptor, phagocytes remain the major target cells. Due to the function of hepatic phagocytic cells in removing blood foreign bodies and the close relationship between liver cells and blood, the liver becomes an important target organ of liposomes; and the rich nutrient environment of the liver provides breeding grounds for many parasites. Thus, try