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自1958年 Steiner 偶然发现口服新霉素可降低血浆胆固醇浓度以来,20多年中不少临床医师用新霉素治疗高胆固醇血症,且认为有效。即使对某些抗药的家族性高胆固醇血症者亦是如此。作者等研究了22种抗菌素对血浆胆固醇的作用。新霉素的常用剂量为每日2g,口服;以后逐渐减量,可减至睡前1次口服0.5g。在一组397例报告中,血浆胆固醇平均降低20～30%。投药时间短者仅2周,长者达8年。口服小剂量新霉素副作用很少,1/3～1/2患者有短暂的腹泻和痉挛性腹痛,一般在1～2周内消失。对肝肾和骨髓造血功能没有影响。大剂量(每日6～12g)口服,少数病例可出现腹泻、
Since Steiner accidentally discovered that oral neomycin can lower plasma cholesterol levels in 1958, more than 20 years many clinicians have used neomycin to treat hypercholesterolemia and found it effective. Even for some resistant familial hypercholesterolemia. The authors studied the effect of 22 antibiotics on plasma cholesterol. Commonly used dose of neomycin daily 2g, oral; gradually tapering, can be reduced to 1 times before going to bed orally 0.5g. In a group of 397 reports, plasma cholesterol was reduced by an average of 20-30%. Short duration of administration of only 2 weeks, the elderly up to 8 years. Oral small doses of neomycin few side effects, 1/3 ~ 1/2 patients with transient diarrhea and spastic abdominal pain, usually disappear within 1 to 2 weeks. No effect on hematopoietic function of liver, kidney and bone marrow. Large doses (6 ~ 12g daily) oral, a small number of cases can occur diarrhea,