人肝细胞在候选药的药物代谢和毒性研究中起着重要作用,然而缺乏可靠的高质量的细胞来源。Nat Biotechnol杂志报道,Azuma等构建了一种免疫缺陷小鼠,可以高效植入人肝细胞,为肝细胞的扩增提供了一个有力的平台。研究者将酪氨酸分解代谢酶延胡索酸乙酰乙酸水解酶(FAH)缺陷鼠与Rag Human hepatocytes play an important role in the study of drug metabolism and toxicity of candidate drugs, however, there is a lack of reliable, high quality source of cells. Nat Biotechnol Magazine reports that Azuma et al. Constructed an immunodeficient mouse that can be efficiently implanted into human hepatocytes to provide a powerful platform for hepatocyte expansion. Researchers will tyrosine catabolism enzyme fumarate acetoacetate hydrolase (FAH) deficient mice and Rag