目的分析乳果糖联合枯草杆菌二联活菌颗粒在治疗小儿功能性便秘上的临床效果。方法选取本院2010年1月~2013年12月诊治的114例小儿功能性便秘患儿作为研究对象。随机将这114例患者分成3组,A组采用乳果糖、枯草杆菌二联活菌颗粒联合应用治疗,B组单独采用乳果糖进行治疗,C组单独采用枯草杆菌二联活菌颗粒进行治疗,三组均采用相同的常规基础治疗。治疗后1个月、2个月、3个月进行随访复查,采集数据后分析比较不同治疗方案患儿功能性便秘的复发率;于3个月后进行总有效率的比较,确定最佳治疗方案。结果在治疗后1个月、2个月、3个月时进行的随访中,三组患儿的功能性便秘情况均有改善,但A组的复发率明显低于B组、C组,P<0.05,差异具有统计学意义;3个月后,在总有效率的评定中,A组的总有效率明显高于B组、C组,P<0.05,差异具有统计学意义。结论乳果糖联合枯草杆菌二联活菌颗粒在治疗小儿功能性便秘上比单独纯粹的治疗方法明显具有优势,此治疗方案较好,复发率低。 Objective To analyze the clinical effect of lactulose combined with Bacillus subtilis and two live bacteria granules in the treatment of children with functional constipation. Methods A total of 114 children with functional constipation who were treated in our hospital from January 2010 to December 2013 were selected as the research object. The 114 patients were randomly divided into three groups. Group A was treated with combination of lactulose and B. subtilis, while group B was treated with lactulose alone. In group C, B. subtilis alone was used for treatment. Three groups were treated with the same conventional basis. After 1 month, 2 months and 3 months after treatment, follow-up and follow-up were conducted. Data were collected and analyzed to compare the recurrence rates of functional constipation in children with different treatment regimens. After 3 months, the total effective rates were compared to determine the best treatment Program. Results The functional constipation was improved in all three groups at 1 month, 2 months and 3 months after treatment, but the recurrence rate in group A was significantly lower than that in group B, C, P <0.05, the difference was statistically significant. After three months, the total effective rate in group A was significantly higher than that in group B and C (P <0.05). The difference was statistically significant. Conclusion lactulose combined with Bacillus subtilis viable particles in the treatment of functional constipation in children than the purely pure treatment has obvious advantages, this treatment is better, the recurrence rate is low.