Survivin(SVV)是IAP(inhibitorofapoptosis)家族的一个新成员。具有抑制细胞凋亡的作用,并在细胞的有丝分裂和胞质分裂中起重要的作用。研究表明SVV是一个肿瘤特异性的抑制凋亡因子它在成熟的终末分化组织中基本无表达,而在胚胎发育过程中和人的肿瘤组织中表达,SVV的过度表达是提示肿瘤预后不良的一个因素,并可能是导致肿瘤细胞耐药性的因素。SVV是肿瘤靶向治疗的一个很好的靶基因蛋白。 Survivin (SVV) is a new member of the IAP (inhibitorofapoptosis) family. It has the effect of inhibiting apoptosis and plays an important role in cell mitosis and cytokinesis. Studies have shown that SVV is a tumor-specific inhibitor of apoptosis, and that it is almost absent in mature, terminally differentiated tissues. Expression in embryonic development and in human tumor tissue, overexpression of SVV suggests poor prognosis of tumors. One of the factors, and may be the factor that causes tumor cell resistance. SVV is a good target gene protein for tumor targeted therapy.