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G蛋白偶联受体-54(GPR-54)是新发现的视黄酸家族成员之一,kisspep-tins是其内源性配体,两者均是哺乳动物体内的肽类物质,主要分布于中枢神经系统的下丘脑、弓状核等多个区域,均与性发育密切相关。实验证明GPR-54突变的大鼠性发育低下,人类发生GPR-54突变者性腺功能低下,不能进入青春期。GPR-54/kisspeptins在调节促性腺激素LH和FSH的释放、促进生殖器官的发育及青春期启动中均具有重要的作用。
G protein-coupled receptor-54 (GPR-54) is a newly discovered member of the retinoic acid family and kisspep-tins is its endogenous ligand, both of which are mammalian peptides, with a predominant distribution In the central nervous system hypothalamus, arcuate nucleus and other regions, are closely related to sexual development. Experiments show that GPR-54 mutations in the sexual development of rats, human GPR-54 mutations in gonadal dysfunction, can not enter adolescence. GPR-54 / kisspeptins play an important role in the regulation of the release of gonadotropins LH and FSH, promotion of reproductive organ development and puberty initiation.