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对１３只兔右心室血浆、肠系膜上静脉血浆、胃液和十二指肠液及６７例健康人和慢性萎缩性胃炎（ＣＡＧ）患者血浆和十二指肠液胃动素（ＭＯＴ）含量的测定表明：１．兔十二指肠液、血浆与胃液ＭＯＴ的浓度比为４∶２∶１，三者间两两比较相差显著（Ｐ＜０．０５）；２．健康人血浆及十二指肠液ＭＯＴ含量分别为１４１．６±５７．３ｐｍｏｌ／Ｌ和３９５．１±１８０．４ｐｍｏｌ／Ｌ。后者是前者的２．８倍；３．ＣＡＧ患者血浆ＭＯＴ含量与健康组比较无显著性差异，十二指肠液的ＭＯＴ含量升高特别显著（Ｐ＜０．００１），且与萎缩及肠化程度有关。说明ＭＯＴ的分泌除有内分泌方式外，还有外分泌或腔内分泌途径，腔内分泌途径可能对维持与调节胃肠道局部运动功能有重要的生理及临床病理学意义。
The plasma and duodenal motilin levels in 13 rabbit right ventricular plasma, superior mesenteric vein, gastric juice and duodenal juice and 67 healthy volunteers and chronic atrophic gastritis (CAG) 1. Rabbit duodenal juice, plasma and gastric juice MOT concentration ratio of 4: 2: 1, the difference between the two was significant (P <0.05); The content of MOT in plasma and duodenal juice in healthy volunteers were 141.6 ± 57.3pmol / L and 395.1 ± 180.4pmol / L, respectively. The latter is 2.8 times the former; 3. There was no significant difference in the content of MOT in plasma between CAG patients and healthy people. The content of MOT in duodenal juice increased significantly (P <0.001), which was related to atrophy and intestinal metaplasia. In addition to the secretion of endocrine motility, there are exocrine or endocrine pathways, the endocrine pathway may have important physiological and clinicopathological significance in maintaining and regulating the local motor function of the gastrointestinal tract.