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一、Ⅰ型变态反应的免疫调控。 免疫球蛋白E（IgE）负责变态反应的介导。Ⅰ型变态反应中,IgE分子通过IgEFc受体与肥大细胞、嗜碱粒细胞结合。当特异抗原与细胞表面的IgE结合时,IgE受体被启动,肥大细胞脱颗粒,释放组织胺、慢反应物质（SRS—A）、嗜酸性细胞趋化因子等炎症反应介质。加之,特应性体质的人,对这些介质的敏感性增高,导致Ⅰ型变态反应的发生。 免疫反应的发生、程度和类型是由许多机制调控的。调控作用在遗传、细胞、分子等不同水平发挥效益。
First, immune regulation of type I allergies. Immunoglobulin E (IgE) is responsible for the mediation of allergies. In type I allergies, IgE molecules bind to mast cells and basophils through the IgEFc receptor. When a specific antigen binds to IgE on the cell surface, IgE receptors are activated, mast cells degranulate, and inflammatory reaction media such as histamine, slow reaction substance (SRS-A), and eosinophil chemokine are released. In addition, atopic people have increased sensitivity to these media, leading to type I allergies. The occurrence, degree and type of immune response are regulated by many mechanisms. Regulatory effects play a role in genetic, cellular, and molecular levels.