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①目的探讨反复呼吸道感染（ＲＩＲ）病儿红细胞免疫和体液免疫功能的变化。②方法检测了３０例ＲＩＲ病儿红细胞免疫和体液免疫功能（ＩｇＧ，ＩｇＭ，ＩｇＡ，补体Ｃ３）的变化，并与５２例健康儿童进行了对照。③结果ＲＩＲ病儿红细胞Ｃ３ｂ受体花环率（ＲＣＲ）明显降低，循环免疫复合物（ＣＩＣ）阳性率明显增高，与对照组相比差异有显著性（ｔ＝１１．４２３，χ２＝６５．９９，Ｐ＜０．０１），而红细胞免疫复合物花环率（ＲＩＣＲ）与对照组相比差异无显著意义（ｔ＝０．７２０，Ｐ＞０．０５）。病儿红细胞促中性细胞吞噬补体调理的酵母菌作用减弱（ｔ＝８．１６６，１３．７００，Ｐ＜０．００１）。同时，病儿血清ＩｇＡ，ＩｇＧ，补体Ｃ３含量较对照组明显降低（ｔ＝６．７５６～８．２７６，Ｐ＜０．０１）。ＲＣＲ与ＩｇＡ，ＩｇＧ和补体Ｃ３含量呈正相关（ｒ＝０．４１２～０．４９７，Ｐ＜０．００１）。④结论红细胞免疫和体液免疫参与了ＲＩＲ发病，且其变化与病情严重程度有关。
Objective To investigate the changes of erythrocyte and humoral immunity in children with recurrent respiratory tract infection (RIR). Methods The changes of erythrocytic and humoral immunity (IgG, IgM, IgA, complement C3) in 30 children with RIR were detected and compared with 52 healthy children. Results The RBC value of C3b receptor in RIR children was significantly decreased, the positive rate of CIC was significantly higher than that in control group (t = 11.423, χ2 = 65.99 , P <0.01). There was no significant difference in RICR between control group and erythrocyte immune complex (t = 0.720, P> 0.05). Erythrocyte pro-neutrophil phagocytosis complement regulation of the role of yeast weakened (t = 8.166, 13.700, P <0.001). At the same time, serum IgA, IgG and complement C3 levels in sick children were significantly lower than those in control group (t = 6.756-8.276, P <0.01). RCR and IgA, IgG and complement C3 was positively correlated (r = 0.412 ~ 0.497, P <0.001). ④ Conclusion RBC immunity and humoral immunity are involved in the pathogenesis of RIR, and its changes are related to the severity of the disease.