论文部分内容阅读
目的与方法 将 83例慢性病毒性肝炎及肝硬化患者肝穿取得的肝组织 ,按纤维化程度分期 ,应用ELISA法检测其血清TNF -α和IL - 6水平。结果 血清TNF -α和IL - 6水平在肝纤维化S2 、S3及S4 期比正常对照组明显升高 (P <0 0 0 1) ,且随着纤维化程度的加重而不断升高。血清TNF -α和IL - 6水平与血清HA、HPCⅢ、LN及IV -C水平呈低～中度的正相关 (P <0 0 1) ;与肝组织纤维化程度计分呈中～高度的正相关 (P <0 0 0 1)。结论 血清TNF -α和IL - 6水平与肝纤维化程度密切相关 ,TNF -α和IL - 6参与了肝纤维化的形成和发展。
PURPOSE AND METHODS Totally 83 patients with chronic viral hepatitis and liver cirrhosis were divided into three groups according to the degree of fibrosis. Serum levels of TNF - α and IL - 6 were measured by ELISA. Results Serum levels of TNF - α and IL - 6 were significantly increased in S2, S3 and S4 liver fibrosis compared with those in normal control group (P <0.01 01), and increased with the degree of fibrosis. The levels of serum TNF-α and IL-6 were positively correlated with the levels of serum HA, HPCⅢ, LN and IV-C at low to moderate levels (P <0.01). The scores of liver fibrosis were moderate to high Positive correlation (P <0 0 0 1). Conclusion Serum levels of TNF - α and IL - 6 are closely related to the degree of liver fibrosis. TNF - α and IL - 6 are involved in the formation and development of hepatic fibrosis.