叉头框蛋白p1(Foxp1)是一种属于叉头框(Forkhead box,Fox)转录因子家族的转录因子,Foxp1最早克隆于小鼠B细胞白血病细胞系,较早的研究表明Foxp1对生物体器官包括心脏和肺的正常发育起着重要的调控作用,且在多种人类肿瘤中异常表达而抑制或促进肿瘤发生发展。最近越来越多的证据表明,Foxp1对免疫系统细胞的发育和功能具有重要的调控作用。本文结合Foxp1调控T细胞发育和功能的最新进展,就Foxp1在免疫系统中的作用进行综述。 Foxp1 is a transcription factor belonging to the family of Forkhead box (Fox) transcription factors. Foxp1 was first cloned in the mouse B cell leukemia cell line. Earlier studies have shown that Foxp1 binds to biological organs Including the normal development of the heart and lungs, play an important regulatory role and are abnormally expressed in a variety of human tumors to inhibit or promote tumorigenesis. More and more recent evidence shows that Foxp1 plays an important regulatory role in the development and function of immune system cells. This review summarizes the role of Foxp1 in the immune system in conjunction with the recent advances in Foxp1 regulation of T cell development and function.