本文研究口服强力霉素后中耳渗出液及鼻息肉组织中的药物含量以探索该药在呼吸道粘膜的渗透情况。实验对象为58名长期分泌性中耳炎(SOM)患者和37名鼻息肉患者。全部实验者至少两周未应用过任何抗生素,首次强力霉素剂量200mg,继后100mg/24小时,体重35kg以下者剂量减半,投药次数分别为1、2、3或5次; In this paper, after oral administration of doxycycline in the middle ear exudate and nasal polyps in the drug content to explore the drug in the respiratory tract mucosal penetration. The subjects were 58 long-term secretory otitis media (SOM) patients and 37 patients with nasal polyps. All the experimenters did not use any antibiotics for at least two weeks, the first dose of doxycycline 200mg, followed by 100mg / 24 hours, the weight of less than 35kg dose halved, the number of doses were 1,2,3 or 5 times;