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The effect of the potassium channel blocker 4- aminopyridine (4- AP) on spontaneous upbeat nystagmus (UBN) was investigated with the search coil technique during fixation in different gaze positions and smooth pursuit in a patient before and after ingestion of 10 mg4- AP. UBN was reduced from 8.6 deg/s to 2.0 deg/s by 4- AP causing subjective relief from distressing oscillopsia, and impaired upward smooth pursuit was restored (gains: before medication 0.38; after medication 0.86). In the dark, UBN was slightly stronger and not affected by4- AP. We propose that 4- AP improved the function of cerebellar pathways that mediate gaze holding and smooth pursuit by intensifying the excitability of cerebellar Purkinje cells.
The effect of the potassium channel blocker 4-aminopyridine (4- AP) on spontaneous upbeat nystagmus (UBN) was investigated with the search coil technique during fixation in different gaze positions and smooth pursuit in a patient before and after ingestion of 10 mg 4- AP . UBN was reduced from 8.6 deg / s to 2.0 deg / s by 4- AP causing subjective relief from distressing oscillopsia, and impaired upward smooth pursuit was restored (gains: before 0.38; after 0.86). In the dark, UBN was slightly stronger and not affected by 4- AP. We propose that 4- AP improved the function of cerebellar pathways that mediate gaze holding and smooth pursuit by intensifying the excitability of cerebellar Purkinje cells.