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目的对胺碘酮联合肾素-血管紧张素系统(RAS)抑制剂治疗高血压合并阵发性心房颤动(房颤)的临床效果进行分析与探讨。方法 84例高血压合并阵发性房颤患者,按照入院就诊时间分为对照组和实验组,各42例。对照组患者采用胺碘酮单用治疗,实验组患者在对照组基础上加用贝那普利治疗,比较两组患者的临床治疗效果、血压控制水平以及左心房内径。结果实验组患者治疗总有效率(97.6%)高于对照组(85.7%),差异有统计学意义(P<0.05)。治疗后,实验组患者血压控制水平明显优于对照组,差异有统计学意义(P<0.05)。治疗后实验组患者的左心房内径明显小于对照组,差异有统计学意义(P<0.05)。结论在高血压合并阵发性房颤治疗中应用胺碘酮联合RAS抑制剂治疗,其治疗效果显著,在临床上应用具有重要的价值。
Objective To analyze and discuss the clinical effect of amiodarone combined with renin-angiotensin system (RAS) inhibitor on hypertension and paroxysmal atrial fibrillation (AF). Methods Eighty-four patients with hypertension complicated by paroxysmal atrial fibrillation were divided into control group and experimental group according to the time of hospital admission, with 42 cases in each group. Patients in the control group were treated with amiodarone alone. Patients in the experimental group were treated with benazepril on the basis of the control group, and the clinical effects, blood pressure control and the diameter of the left atrium were compared between the two groups. Results The total effective rate (97.6%) in the experimental group was significantly higher than that in the control group (85.7%) (P <0.05). After treatment, the experimental group of patients with blood pressure control was significantly better than the control group, the difference was statistically significant (P <0.05). After treatment, the left atrial diameter of the experimental group was significantly smaller than that of the control group, the difference was statistically significant (P <0.05). Conclusions The application of amiodarone and RAS inhibitor in the treatment of hypertension complicated by paroxysmal atrial fibrillation has significant therapeutic effect and is of great value in clinical application.