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目的:探讨先天性心脏病的发生与患儿父母孕前、孕期非遗传因素暴露的相关性。方法:采用病例对照分析方法,以面对面访谈形式对先心病患儿父母(观察组)和同期正常儿童父母(对照组)孕前、孕期非遗传因素进行调查研究。采用二分类非条件Logistic回归分析,筛选出与先心病可能相关的危险因素。结果:对两组调查数据进行统计分析未发现与当地先心病发病相关的非遗传性因素。结论:黄岛区内近几年出生缺陷预防工作取得一定效果,仍需加强孕前优生宣教,减少和避免孕前、孕期先心病发病的风险。
Objective: To investigate the correlation between the occurrence of congenital heart disease and the non-genetic factors exposure of pregnant women before pregnancy and during pregnancy. Methods: A case-control study was conducted to investigate the non-genetic factors of pre-pregnancy and pre-pregnancy of parents of children with congenital heart disease (CHD) and normal parents (control group) in the form of face-to-face interview. Logistic regression analysis was used to identify the possible risk factors of CHD. Results: Statistical analysis of the two groups did not reveal any non-genetic factors associated with the development of local congenital heart disease. Conclusion: The prevention of birth defects in Huangdao District has achieved certain results in recent years. There is still a need to strengthen prenatal education so as to reduce and avoid the risk of congenital heart disease before pregnancy and during pregnancy.