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目的观察盐酸前列地尔联合弥可保治疗糖尿病周围神经病变的疗效。方法将86例糖尿病并发神经病变患者随机分为治疗组44例,对照组42例。治疗组以前列地尔10μg加入生理盐水20 ml缓慢静脉注射,1次/d,弥可保500μg肌肉注射1,次/d,连用4周;对照组只用弥可保500μg肌肉注射,1次/d,连用4周。结果治疗4周后,两组神经症状均得到改善,且治疗组TSS评分与对照组比较差异有统计学意义(P<0.05);治疗组四肢疼痛、麻木感觉阈值改善较对照组明显(P<0.05)。结论前列地尔联合弥可治疗糖尿病周围神经病变有较好的疗效。
Objective To observe the curative effect of pridiol hydrochloride and methycobal on diabetic peripheral neuropathy. Methods 86 patients with diabetic neuropathy were randomly divided into treatment group (44 cases) and control group (42 cases). In the treatment group, 10 μg of alprostadil was injected slowly into the vein of 20 ml normal saline once a day, and 500 mg of miconazole was intramuscularly injected once a day for 4 weeks. In the control group, 500 μg of miconazole was administered intramuscularly / d, used in conjunction for 4 weeks. Results After 4 weeks of treatment, the neurological symptoms of both groups were improved, and the TSS score of the treatment group was significantly different from that of the control group (P <0.05). The improvement of limb pain and numbness threshold in the treatment group was more obvious than that of the control group (P < 0.05). Conclusion Alprostadil combined with Mi can treat diabetic peripheral neuropathy has a good effect.