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冠心病（ＣＨＤ）危险的增加与性激素的不足密切相关。我们测定了６６０名健康妇女（１４～７５岁）绝经期前、后血脂和脂蛋白的浓度。观察到总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、低密度脂蛋白胆固醇（ＬＤＬ—Ｃ）、极低密度脂蛋白胆固醇（ＶＬＤＬ—Ｃ）、ＴＣ／ＨＤＬ—Ｃ和ＬＤＬ—Ｃ／ＨＤＬ—Ｃ的比率随年龄增大而明显增高。绝经后妇女的ＴＧ、ＴＣ、ＬＤＬ—Ｃ、ＶＬＤＬ—Ｃ、ＴＣ／ＨＤＬ—Ｃ和ＬＤＬ—Ｃ／ＨＤＬ—Ｃ比率明显高于绝经前的妇女（Ｐ＜０．００１或０．００５），而高密度脂蛋白胆固醇（ＨＤＬ—Ｃ）无明显变化。这些变化可以部分解释绝经妇女ＣＨＤ发病率增高的现象。
Increased risk of coronary heart disease (CHD) and lack of sex hormones are closely related. We measured blood levels of lipids and lipoproteins before and after menopause in 660 healthy women (14-75 years of age). Total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), TC / HDL-C and LDL-C / HDL- C ratio increased significantly with age. The rates of TG, TC, LDL-C, VLDL-C, TC / HDL-C and LDL-C / HDL-C in postmenopausal women were significantly higher than those in premenopausal women (P <0.001 or 0.005) High-density lipoprotein cholesterol (HDL-C) no significant change. These changes can partly explain the increased incidence of CHD in postmenopausal women.