目的观察四联疗法治疗消化性溃疡的疗效和不良反应。方法将消化性溃疡患者44例随机分为试验组和对照组各22例。对照组给予克拉霉素、雷贝拉唑、阿莫西林三联疗法治疗,试验组在对照组治疗的基础上给予枸橼酸铋钾治疗。比较2组临床疗效、Hp根除效果及不良反应发生情况。结果试验组总有效率为90.9%高于对照组的72.7%,差异有统计学意义(P<0.05)。试验组患者Hp转阴率为81.8%高于对照组的63.6%,差异有统计学意义(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论四联疗法治疗消化性溃疡疗效显著,减轻了患者的痛苦,值得在临床推广和使用。 Objective To observe the curative effect and adverse reactions of quadruple therapy on peptic ulcer. Methods Forty-four patients with peptic ulcer were randomly divided into experimental group and control group with 22 cases each. The control group was treated with clarithromycin, rabeprazole and amoxicillin triple therapy. The experimental group was treated with bismuth potassium citrate on the basis of the control group. The clinical efficacy, Hp eradication and adverse reactions were compared between the two groups. Results The total effective rate of the experimental group was 90.9%, which was significantly higher than that of the control group (72.7%) (P <0.05). The Hp negative conversion rate in the experimental group was 81.8% higher than 63.6% in the control group, the difference was statistically significant (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion The quadruple therapy is effective in treating peptic ulcer and alleviates the suffering of patients, which is worthy of clinical promotion and use.