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本文报告用ELISA法检测了SLE及其它结缔组织病病人的抗心磷脂抗体(ACA)。53/110例SLE、7/9例SS、3/10例PSS和178例PM及DM病人ACA阳性。ACA的检测有助于上述疾病的诊断。ACA阳性SLE病人与ACA阴性SLE病人比较,网状青斑(31.4%比8.6%)、皮肤血管炎(68.6%比40%)、肺脏受累(22.9%比8.7%)、血小板减少(68.6%比37.1%)和抗Ro/SSA抗体阳性(57.9%比30.3%)发生率高。5例有血栓形成的病人中,1例有ACA。本组其它结缔组织病中,ACA阳性病人多数表现皮肤血管炎和高r球蛋白血症。
This article reports the detection of anti-cardiolipin antibodies (ACA) in patients with SLE and other connective tissue diseases by ELISA. 53/110 cases of SLE, 7/9 cases of SS, 3/10 cases of PSS and 178 cases of PM and DM patients ACA positive. The detection of ACA contributes to the diagnosis of the above diseases. Reticulopathies (31.4% vs. 8.6%), cutaneous vasculitis (68.6% vs. 40%), lung involvement (22.9% vs. 8.7%), and thrombocytopenia (68.6%) were associated with ACA-positive SLE patients compared with ACA-negative SLE patients 37.1%) and anti-Ro / SSA antibodies (57.9% vs. 30.3%). Among 5 patients with thrombosis, 1 had ACA. In this group of other connective tissue disease, ACA-positive patients most of the performance of skin vasculitis and hypergammaglobulinemia.