鸟苷酸环化酶(GC)有两种形式:位于细胞膜中的结合型和分布于胞浆中的游离型。有许多报道,心房利钠肽(ANP)能刺激GC活性,使cGMP增高。最近,Chinkers等证明,ANP的受体即为结合型的GC。他们提取并克隆出大鼠GC完整的cDNA,该基因包括1057个氨基酸编码区,其中从N末端起有441个氨基酸位于细胞膜外,567个氨基酸位于细胞膜内。该酶的分子量为115852,与曾报道的结合型GC的分 There are two forms of guanylate cyclase (GC): the binding type located in the cell membrane and the free type distributed in the cytoplasm. There are many reports that atrial natriuretic peptide (ANP) can stimulate GC activity and increase cGMP. Recently, Chinkers et al. Demonstrated that the receptor for ANP is the bound GC. They extracted and cloned the complete cDNA of the rat GC, which contains 1057 amino acid coding regions, of which 441 amino acids from the N-terminus are located outside the cell membrane and 567 amino acids are located within the cell membrane. The enzyme has a molecular weight of 115852, which has been reported as a fraction of binding type GC