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目的：探讨人参茎叶皂甙抗休克及应激的可能机理。方法：采用放免法测定了失血性休克组（HS）和用人参皂甙预治疗组（HSG）血浆中ACTH、皮质醇、醛固酮的含量。用荧光法测定了血浆中去甲肾上腺素（NE）、5一羟色胺（5—HT）的含量。结果：人参茎叶甙预治疗组（HSG）在失血后第4小时和第5小时时，NE和5—HT的含量比失血性休克组（HS）均明显减少（P＜0．01）而接近失血前水平，皮质醇和醛固酮的含量，人参茎叶皂甙预治疗组（HSG）在失血后4、sh逐渐回降，而失血性休克组（HS）在失血后第4小时和第5小时升高，两组相比差异均显著（P＜0．o1）。结论；人参茎叶皂甙不仅能阻止休克时NE、5—HT含量的增加，还能通过调节肾上腺皮质系统的作用，使休克晚期皮质醇和醛固酮的分泌减少，从而起到抗休克及应激的作用。
Objective: To investigate the possible mechanism of anti-shock and stress in Ginseng stem and leaf saponin. METHODS: Plasma levels of ACTH, cortisol, and aldosterone in the hemorrhagic shock group (HS) and the ginsenoside pretreatment group (HSG) were determined by radioimmunoassay. The levels of noradrenaline (NE) and 5-hydroxytryptamine (5-HT) in plasma were determined by fluorescence. RESULTS: At the 4th hour and 5th hour after the blood loss, the content of NE and 5-HT in the ginseng stem-leaf stem pretreatment group (HSG) was significantly lower than that in the hemorrhagic shock group (HS) (P<0.01). Near pre-bleeding levels, cortisol and aldosterone levels, the ginseng stem and leaf saponin pretreatment group (HSG) gradually decreased after blood loss and sh, and hemorrhagic shock group (HS) rose at the 4th and 5th hours after blood loss. The difference between the two groups was significant (P<0.o1). Conclusion: Ginseng stem and leaf saponins can not only prevent the increase of NE and 5-HT contents during shock, but also can reduce the secretion of cortisol and aldosterone during the shock by regulating the function of adrenocortical system, and thus play an anti-shock and stress effect. .