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目的通过检测ER、CD10和CD44v3在低度恶性子宫内膜间质肉瘤与富于细胞型子宫平滑肌瘤中的表达,探讨其用于辅助鉴别诊断这两种肿瘤的价值和意义。方法免疫组化检测15例低度恶性子宫内膜间质肉瘤及15例富于细胞型子宫平滑肌瘤标本中ER、CD10和CD44v3的表达情况。结果 15例低度恶性子宫内膜间质肉瘤ER阳性表达率为3/15(20%),而富于细胞型平滑肌瘤ER阳性表达率为13/15(87%);15例低度恶性子宫内膜间质肉瘤CD10的阳性表达率为12/15(80%),而富于细胞型子宫平滑肌瘤CD10的阳性表达率为5/15(33%);15例低度恶性子宫内膜间质肉瘤的CD44v3阳性表达率为3/15(20%),而富于细胞型子宫平滑肌瘤的CD44v3阳性表达率为6/15(40%),以上结果经统计学分析,P<0.01,差异有统计学意义。结论ER、CD10和CD44v3表达的检测,可用于辅助鉴别诊断低度恶性子宫内膜间质肉瘤和富于细胞型子宫平滑肌瘤。
Objective To investigate the value and significance of the expression of ER, CD10 and CD44v3 in low grade endometrial stromal sarcoma and rich type cell uterine leiomyoma. Methods Immunohistochemistry was used to detect the expression of ER, CD10 and CD44v3 in 15 cases of low grade endometrial stromal sarcoma and 15 cases of cell type uterine leiomyoma. Results The positive expression rate of ER in 15 cases of low grade endometrial stromal sarcoma was 3/15 (20%), while the positive expression rate of ER in 13 cases (87%) was rich in cell type leiomyoma; 15 cases of low grade The positive rate of CD10 expression in malignant endometrial stromal sarcoma was 12/15 (80%), while the positive rate of CD10 in uterine leiomyoma was 5/15 (33%). In 15 cases of low grade malignant uterus The positive rate of CD44v3 in endometrial stromal sarcoma was 3/15 (20%), while the positive rate of CD44v3 in cell-rich uterine leiomyoma was 6/15 (40%). The above results were statistically analyzed. P <0.01, the difference was statistically significant. Conclusion The detection of ER, CD10 and CD44v3 expression can be used to assist in the differential diagnosis of low grade endometrial stromal sarcoma and cell type uterine leiomyoma.