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乙胺碘呋酮(Amiodarone,AM)是一种有效的抗心律不齐药,在人体产生作用慢而持久,这完全不同于其他抗心律不齐药。它的药理作用与血清浓度无关。最近报告乙胺碘呋酮或其代谢产物脱乙基乙胺碘呋酮(Desethylamiodarone,DAM)肝内T_4转化T_3的强力抑制剂,提示对心肌收缩力的抑制作用可能与能被利用的T_3减少有关。作者研究喂养AM大鼠(500mg/kg饲料)6～8周,导致T_4转化T_3减少后肝、心细胞内变化.由于α-磷酸甘
Amiodarone (AM) is a potent antiarrhythmic drug that has a slow, long-lasting effect on the body that is completely different from other antiarrhythmic drugs. Its pharmacological effects have nothing to do with serum concentration. A recent report of potent inhibitors of amiodarone or its metabolite desethylamiodarone (DAM) translocating T_3 in the liver suggests that inhibition of myocardial contractility may be related to reduction of T_3 that can be utilized related. The study of feeding AM rats (500mg / kg feed) for 6 to 8 weeks, resulting in reduced T_4 T_3 liver and heart cells after the change due to α-phosphate