目的观察经颞浅动脉灌注化疗治疗无法切除的晚期上颌恶性肿瘤的疗效和毒副反应。方法 16例无法切除局部晚期上颌恶性肿瘤患者,行选择性颞浅动脉插管后,根据化疗方案用微量输液泵经导管远心端药池输注相应化疗药物:多西他赛60~75mg/m2匀速灌注2h,d1;顺铂75mg/m2大剂量冲击2h,d1;氟尿嘧啶500mg/m2连续灌注120h,d1~d5;吡柔比星25mg/m2匀速灌注2h,d1~d3;吉西他滨1000mg/m2连续滴注30min,d1、d8。21天为1个周期,2个周期分别采用RECIST 1.1标准和NCI CTC 3.0标准评价近期疗效和毒副反应并随访远期生存情况。结果 16例均可评价近期疗效,其中CR 1例,PR 10例,SD 5例,RR为68.8%,DCR为100.0%。14例获随访(87.5%),中位生存期和无进展生存期分别为26.0个月和4.0个月。全组未有4级毒副反应发生,无治疗相关性死亡,3级毒副反应主要为1例耳廓部分坏死、3例贫血及1例骨髓抑制,其余均为1~2级。结论无法切除的晚期上颌恶性肿瘤经动脉灌注化疗后能够取得较为满意的治疗效果,毒副反应可耐受。 Objective To observe the efficacy and side effects of transcatheter arterial infusion chemotherapy for unresectable maxillary malignant tumors. Methods Sixteen patients with locally advanced maxillary malignant tumor who underwent selective temporal superficial arterial cannulation were treated with the infusion of the corresponding chemotherapeutic drugs via micropipette infusion pump via the catheterized distal venous drug infusion according to the chemotherapy regimen: docetaxel 60 ~ 75mg / m2 uniform infusion 2h, d1; cisplatin 75mg / m2 high-dose impact 2h, d1; fluorouracil 500mg / m2 continuous perfusion 120h, d1 ~ d5; pirarubicin 25mg / m2 uniform perfusion 2h, d1 ~ d3; gemcitabine 1000mg / m2 Continuous infusion of 30min, d1, d8.21 days for a cycle, two cycles RECIST 1.1 standard and NCI CTC 3.0 standard evaluation of short-term efficacy and side effects and follow-up long-term survival. The results of 16 cases can evaluate the short-term efficacy, including CR 1 cases, PR 10 cases, SD 5 cases, RR was 68.8%, DCR was 100.0%. Fourteen patients were followed up (87.5%). The median survival and progression-free survival were 26.0 months and 4.0 months respectively. There was no level 4 toxic and side effects in the whole group and no treatment-related deaths. Grade 3 toxicities were mainly 1 case of partial auricle necrosis, 3 cases of anemia and 1 case of myelosuppression, and the rest were grade 1 to 2. Conclusion The unresectable advanced maxillary malignant tumor can obtain more satisfactory curative effect after arterial infusion chemotherapy and the side effects can be tolerated.