Facile construction of targeted pH-responsive DNA-conjugated gold nanoparticles for synergistic phot

来源 :中国化学快报:英文版 | 被引量 : 0次 | 上传用户:sabot
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Recently,stimuii-responsive DNA nano structure-based nanodevices have bee n applied for cancer therapy.In this study,pH-responsive i-motifDNA was modified on gold nanoparticles(AuNPs)via a facile,time-saving freeze-thaw method and utilized to construct st
其他文献
Quaternary ammonium salts(QASs) are excellent candidates for treating stubborn bacterial infections caused by biofilms due to their high sterilization efficiency and potential inhibition of the development of drug resistance.However,the inherent toxicity
Despite of the promising achievements of immune checkpoints blockade therapy(ICB) in the clinic,which was often limited by low objective responses and severe side effects.Herein,we explored a synergistic strategy to combine in situ vaccination and gene-me
Antimalarial chemotherapies endowed with effectiveness against drug-resistant parasites and good safety are urgently required in clinical.Our previous research revealed that clinical phaseⅡantitumor drug Quisinostat was a promising antimalarial prototype
Understanding the physical mechanisms governing aggregation-induced-emission(AIE)and aggrega-tion-caused-quenching plays a vital role in developing functional A
对CRH2A型动车组荧光灯逆变器工作原理进行分析,提出可快速判断故障原因并修复的方法,通过试验分析进一步验证该方法的正确性和实用性,大大降低维修成本,具有良好的实用价值和行业应用前景。
基于大数据技术的深入发展,发电企业也逐步开始着手于生产、管理方面的数字化转型。大数据技术不仅能为发电企业的数据挖掘和分析提供支持,还能为企业的生产管理和设备运维提供依据。本文通过电力大数据平台,结合发电企业在实际运行过程中的需要,重点分析了大数据技术在数据采集、技术监督管理、设备状态预警、运行优化中的应用,开发出适用于发电企业的基于Hadoop架构的电力大数据平台,并对大数据平台在发电企业的广阔发展前景进行展望。
The improvement in accuracy of in vitro diagnosis has always been the focus of early screening of thyroid dysfunction.We constructed a microfluidic chip based on a polystyrene polymer substrate.Total triiodothyronine(TT3),total thyroxine(TT4),free triiodo
随着锂电池的应用成为热点,锂电池可靠性的研究也被重视起来。对于移动终端设备的用户来说,了解当下电量非常重要,人们可以根据剩余的电量来决定接下来如何对待该电子设备;而对于企业来说,SOC的准确估算,有利于产品可靠性评估以及后续应用的开发。
Although the antitumor drug cabazitaxel shows great therapeutic potential,its high toxicity and poor water solubility limit its utility.However,the use of stimuli-responsive prodrugs is a promising strategy for overcoming these limitations.Herein,we repor
The reactive oxygen species(ROS)are tightly associated with endoplasmic reticulum(ER)stress.Thus,the deep and visual insight of aberrant ROS fluctuations in the