目的：研究ＥｐｓｔｅｉｎＢａｒｒ 病毒（ＥＢＶ）与腮腺淋巴上皮瘤样癌（ｌｙｍｐｈｏｅｐｉｔｈｅｌｉｏｍａｌｉｋｅｃａｒｃｉｎｏｍａ，ＬＥＬＣ）的关系，并检测瘤细胞内ＥＢＶ 基因编码产物。方法：作者收集了中山医科大学所属病理科１９８６ 年１ 月至１９９５ 年１２ 月间３２ 例腮腺ＬＥＬＣｓ．。３２ 例ＬＥＬＣ石蜡包埋标本再次切片。采用免疫组化和原位核酸杂交法检测瘤细胞内ＥＢＶ 基因表达产物。结果：（１） 在１２５例腮腺癌中有３２ 例淋巴上皮瘤样癌，占总病例的２５－６％ （３２／１２５） 。（２）所有３２ 例腮腺ＬＥＬＣ组织中均有数量不等的ＥＢＮＡ１ 和ＥＢＥＲｓ 阳性瘤细胞。（３）２７ 例ＬＥＬＣ 组织中部分瘤细胞表达ＬＭＰ１ 。（４） 所有标本中均未见ＺＥＢＲＡ 阳性细胞。（５）３２例腮腺ＬＥＬＣ组织中ＥＡＤ、ＶＣＡ和ＭＡ的阳性表达率分别为７１－９ ％（２３／３２） 、６８－８ ％（２２／３２） 和１２－５％ （４／３２） 。结论：（１） 在鼻咽癌高发的广州地区，腮腺ＬＥＬＣ的发病率也较高。（２）腮腺ＬＥＬＣ 组织中均有ＥＢ病毒感染。（３）ＥＢ病毒在腮腺ＬＥＬＣ的感染主要为潜伏Ⅱ型，即表达ＥＢＮＡ１ 、ＥＢＥＲｓ 和ＬＭＰ１ Objective: To study the relationship between EpsteinBarr virus (EBV) and lymphoepitheliomalikecarcinoma (LELC) and to detect the EBV gene coding products in tumor cells. METHODS: The authors collected 32 parotid LELCs from January 1986 to December 1995 in the Department of Pathology, Sun Yat-sen University. . Thirty-two LELC paraffin-embedded specimens were sectioned again. The expression of EBV gene in tumor cells was detected by immunohistochemistry and in situ hybridization. Results: (1) There were 32 cases of lymphoepithelioma in 125 cases of parotid gland carcinoma, accounting for 25-6% (32/125) of the total cases. (2) The number of EBNA-1 and EBERs-positive tumor cells in all 32 parotid LELC tissues was different. (3) 27 cases of LELC tissue part of the tumor cells express LMP 1. (4) No ZEBRA positive cells were found in all specimens. (5) The positive expression rates of EAD, VCA and MA in parotid gland LELC tissues were 71-9% (23/32), 68-8% (22/32) and 12-5% (4/32) respectively ). Conclusions: (1) The incidence of parotid LELC is also higher in Guangzhou with high incidence of NPC. (2) Epstein-Barr virus infection in parotid LELC tissues. (3) Epstein-Barr virus infection in the parotid LELC mainly latent type Ⅱ, that the expression of EBNA 1, EBERs and LMP 1